化合物用於製備治療自體免疫神經疾病及/或神經退化性疾病之藥物的用途

細胞生物製劑產品與關鍵原料開發驗證計畫

黃國魁、潘一紅、溫淑芳、林孟男、呂亦晃、郭宗鏗、呂居勳、李志忠、楊雅燕、廖嘉鴻、林佩欣

提供一種治療自體免疫神經疾病及/或神經退化性疾病的方法。此方法包括對一需要之個體投予一有效量之具有式(I)、式(II)或式(III)之至少一化合物，或其幾何異構物(geometric isomer)、鏡像異構物(enantiomer)、非鏡像異構物(diastereomer)或藥學上可接受的鹽類： ； ； ，其中 為一單或雙鍵，X為NCH3或CH2，Y為不存在、O或N，Z為O或N，R1為H、OH，且R2為不存在、H、C1-C8烷基、-(C=O)-烷基、-(C=O)-芳基、-(C=O)-烷基-芳基、-(C=O)-雜芳基、環烷基或雜環烷基，其視需要而被一或多個之-OH、-NO2、-NH2、-NR3R4、羰基、烷氧基、烷基或-OCF3所取代，其中R3與R4獨立地為H、烷基、-SO2CH3、-(C=O)-CH3或-(C=O)-NH2。

A method for treating an autoimmune neurological disease and/or a neurodegenerative disease is provided.  The method includes administering an effective amount of at least one compound having Formula (I), Formula (II) or Formula (III), or its geometric isomer, enantiomer or diastereomer to a subject in need thereof:    Formula (I);    Formula (II);   Formula (III), wherein   is a single or double bond, X is NCH3 or CH2, Y is null, O or N, R1 is H, OH, and R2 is null, H, C1-C8 alkyl, –(C=O)–alkyl, –(C=O)–aryl, –(C=O)–alkyl-aryl, –(C=O)–heteroaryl, cycloalkyl or heterocycloalkyl, which optionally substituted by one or more of –OH, –NO2, –NH2, –NR3R4, carbonyl, alkoxyl, alkyl or –OCF3, wherein R3 and R4 independently are H, alkyl, –SO2CH3, –(C=O)-CH3 or –(C=O)-NH2.