含藥多層薄膜與其形成方法

細胞生物製劑產品與關鍵原料開發驗證計畫

沈欣欣、王羽淇、林立信、楊明嘉、黃秀華、蘇良晟、趙櫻雪、黃靖恩

提供一種含藥多層薄膜。該含藥多層薄膜包括：一含藥層；以及一抗沾黏層於該含藥層之一表面之上。該含藥層係由一第一組成物所構成，該第一組成物包括一第一高分子材料與一藥物，該第一高分子材料包括擇自由以下所組成之群組之至少一個：聚乳酸(polylactic acid, PLA)與聚乙二醇(polyethylene glycol, PEG)，而該第一高分子材料與該藥物之重量比為約1:0.01-0.3。該抗沾黏層係由一第二組成物所構成，該第二組成物包括一第二高分子材料，該第二高分子材料包括擇自由以下所組成之群組之至少一個：聚乳酸與聚乙二醇。

A drug-containing multilayer film provided.  The drug-containing multilayer film includes: a drug-containing layer; and an anti-adhesion layer on a surface of the drug-containing layer.  The drug-containing layer is composed of a first composition including a first polymer material and a drug, and the first polymer material includes at least one selected from the group consisting of: polylactic acid (PLA) and polyethylene glycol (PEG), and the weight ratio of the first polymer material to the drug is about 1: 0.01-0.3.  The anti-adhesion layer is composed of a second composition, and the second composition includes a second polymer material, and the second polymer material includes at least one selected from the group consisting of polylactic acid and polyethylene glycol.