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專利資訊

年度
111
領域
執行單位
專利名稱
可撓性水合固化骨再生材料
計畫名稱
可撓性水合固化骨再生材料開發計畫
專利發明人
核准國家
專利性質
獲證日期
專利期間
技術摘要(中)
本技術產品以四鈣磷酸鹽 (Tetracalcium phosphate, TTCP)做為基底,並以特定比例混合一水磷酸二氫鈣 (Monocalcium phosphate monobasic, MCPM)後結合膠原蛋白以冷凍乾燥成型技術製作出具可撓性的高分子/生醫陶瓷支架,而製作出的支架於後續結合MCPM/磷酸根離子溶液後可進行自硬化完成產品最終應用型態,適用於填補複雜骨缺損型態之功能。此外結合次微米製程技術以及離子誘導技術,提升骨修復效果。在一系列的效果驗證結果中發現,固化後之高分子/生醫陶瓷支架初期具有良好機械強度、生物相容性以及優異之骨細胞分化/礦化效果。有鑒於此,高分子/生醫陶瓷支架具優越的生醫潛能,並可作為突破目前骨科臨床傳統骨填補物瓶頸的關鍵。
技術摘要(英)
This technical product using tetracalcium phosphate (TTCP) as matrix, and mixed with monocalcium phosphate monobasic (MCPM) in a specific proportion, and then combined with collagen. Freeze-drying molding technology was then utilized to produce flexible products. The prepared polymer/biomedical ceramic scaffold can be self-hardening after being combined with phosphate ion solution to complete the final application form of the product, which is suitable for filling the function of complex bone defect types. In addition, sub-micron process technology and ion induction technology which is applied in the product could improve the bone repair effect. In a series of effect verification results, it was found that the hardened ceramic scaffold had good mechanical strength, biocompatibility and excellent bone cell differentiation/mineralization effect at the initial stage. In view of this, the polymer/bioceramic scaffold has excellent biomedical potential and can be used as the key to break through the bottleneck of the traditional grafts in orthopaedic clinics.
聯絡人員
邱冠語
電話
07-6955298#254
傳真
07-6955247
電子信箱
kychiu@mail.mirdc.org.tw
更新日期:2024-08-15

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